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1.
Acta Cir Bras ; 35(9): e202000905, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33084735

RESUMO

PURPOSE: To determine the nephroprotective effect of NAC and Montelukast Sodium administration against the development of renal damage associated with long warm renal ischemia. METHODS: Twenty-seven rats were randomly divided into 3 study groups, which received NAC, montelukast and placebo, and 3 rats were included in the sham-treated control group. Medications were given 3 days before the procedure. DMSA renal scintigraphy was performed before and after surgery. The right renal pedicle was occluded for 45 min to induce ischemia and then subjected to reperfusion for 6 h (I/R groups). RESULTS: On pathological examination, the mean pathological scores of the montelukast and NAC groups were significantly lower than those of the placebo group. (p <0.05). In biochemical examination, significant differences were found in all parameter levels between the placebo group and the montelukast and NAC groups. (p <0.05) When postoperative DMSA renal scintigraphy measurements and renal function levels were compared, significant differences were found between the montelukast and NAC groups and the placebo and sham groups. CONCLUSION: The administration of NAC and montelukast sodium was seen to have a nephroprotective effect against the development of renal damage associated with warm renal ischemia.


Assuntos
Acetatos , Acetilcisteína , Quinolinas , Traumatismo por Reperfusão , Acetatos/farmacologia , Acetilcisteína/farmacologia , Animais , Ciclopropanos , Rim/irrigação sanguínea , Quinolinas/farmacologia , Ratos , Ratos Wistar , Traumatismo por Reperfusão/prevenção & controle , Succímero , Sulfetos , Tomografia Computadorizada por Raios X
2.
Acta cir. bras ; 35(9): e202000905, 2020. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1130676

RESUMO

Abstract Purpose To determine the nephroprotective effect of NAC and Montelukast Sodium administration against the development of renal damage associated with long warm renal ischemia. Methods Twenty-seven rats were randomly divided into 3 study groups, which received NAC, montelukast and placebo, and 3 rats were included in the sham-treated control group. Medications were given 3 days before the procedure. DMSA renal scintigraphy was performed before and after surgery. The right renal pedicle was occluded for 45 min to induce ischemia and then subjected to reperfusion for 6 h (I/R groups). Results On pathological examination, the mean pathological scores of the montelukast and NAC groups were significantly lower than those of the placebo group. (p <0.05). In biochemical examination, significant differences were found in all parameter levels between the placebo group and the montelukast and NAC groups. (p <0.05) When postoperative DMSA renal scintigraphy measurements and renal function levels were compared, significant differences were found between the montelukast and NAC groups and the placebo and sham groups. Conclusion The administration of NAC and montelukast sodium was seen to have a nephroprotective effect against the development of renal damage associated with warm renal ischemia.


Assuntos
Animais , Ratos , Acetilcisteína/farmacologia , Quinolinas/farmacologia , Traumatismo por Reperfusão/prevenção & controle , Acetatos/farmacologia , Sulfetos , Tomografia Computadorizada por Raios X , Ratos Wistar , Succímero , Ciclopropanos , Rim/irrigação sanguínea
3.
Urology ; 85(1): 274.e9-13, 2015 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-25530405

RESUMO

OBJECTIVE: To determine the efficacy of dexpanthenol applied early after urethral trauma for preventing inflammation and spongiofibrosis. MATERIALS AND METHODS: Twenty-seven rats were randomized and divided into 3 groups, with 9 rats in each group. The urethras of all rats were traumatized with a pediatric urethrotome knife at 6-o' clock. For 14 days, group I was given 0.9% saline twice a day (control group), group II was given dexpanthenol 500 mg/kg ampules once a day and 0.9% saline once a day, and group III was given dexpanthenol 500 mg/kg ampules twice a day intraurethrally using a 22 ga catheter sheath. On day 15, the penises of the rats were degloved to perform penectomy. RESULTS: The mean fibrosis scores were 2.4, 2.2, and 1.4, and mean inflammation scar scores were 2, 1.4, and 1.3 in groups I, II, and III, respectively. There was a significant difference between groups I and II for inflammation (P = .011); however, the difference for fibrosis was not significant (P = .331). The differences between groups I and III were statistically significantly different both for inflammation and fibrosis (P = .004 and P = .003, respectively). Groups II and III were not different significantly for inflammation (P = .638); however, there was less fibrosis in group III, in which high-dose dexpanthenol was administered. CONCLUSION: We showed that dexpanthenol applied early after urethral trauma significantly decreased inflammation and spongiofibrosis. We hope that our study will help to decrease strictures after urethral trauma and contribute to pharmaceutical investigations aiming to improve the success of the surgery for urethral strictures.


Assuntos
Ácido Pantotênico/análogos & derivados , Uretra/lesões , Uretra/patologia , Cicatrização/efeitos dos fármacos , Animais , Fibrose/prevenção & controle , Ácido Pantotênico/administração & dosagem , Ratos , Ratos Wistar
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